Tuesday, August 24, 2010

In most cases, differentiation is controlled at which level?

a. replication of the DNA


b. nucleosome formation


c. transcription


d. translation


e. post-translational activation of the proteinsIn most cases, differentiation is controlled at which level?
I'm having a hard time with the cell biologist's answer.





Cell differentiation is controlled by EPIGENETIC regulation of gene expression, that is, by control of gene transcription. It would be energectically very, very inefficient for cells to make large numbers of UNNEEDED proteins and then post-translationally modify or activate just the proteins that a specific cell type would need.





So, I believe the best answer is c. transcription (via epigenetic regulation such as promoter methylation and histone modifications).





Of course, I could be wrong (it wouldn't be the first time!).





Best wishes and good luck.
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